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MGP003754

Record overview

MGPD IDMGP003754
Gene ID8942
SpeciesHomo sapiens (Human)
Gene Namekynureninase
Gene Symbol KYNU
SynonymsKYNUU;
Alternate nameskynureninase; KYNU; L-kynurenine hydrolase;
Chromosome2
Map Location2q22.2
EC Number3.7.1.3
SummaryKynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
OrthologsView orthologs and multiple alignments for KYNU

Proteins

kynureninase isoform a
Refseq ID:NP_001186170
Protein GI:312839880
UniProt ID:Q16719
mRNA ID:NM_001199241
Length:465
RefSeq Status:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAY
GHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLR
IEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP
ALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERG
CQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
 
kynureninase isoform a
Refseq ID:NP_003928
Protein GI:4504937
UniProt ID:Q16719
mRNA ID:NM_003937
Length:465
RefSeq Status:
Protein sequence is identical to GI:312839880 (mRNA isoform)
 
kynureninase isoform b
Refseq ID:NP_001028170
Protein GI:74101437
UniProt ID:Q16719
mRNA ID:NM_001032998
Length:307
RefSeq Status:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAY
GHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLR
IEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKP
ARSEFFN
 
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