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MGP003758

UniProt Annotations

Entry Information
Gene Namemaltase-glucoamylase (alpha-glucosidase)
Protein EntryMGA_HUMAN
UniProt IDO43451
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityHydrolysis of terminal (1->4)-linked alpha-D- glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.
Catalytic ActivityHydrolysis of terminal, non-reducing (1->4)- linked alpha-D-glucose residues with release of alpha-D-glucose.
FunctionMay serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
PtmDoes not undergo intracellular or extracellular proteolytic cleavage.
PtmN- and O-glycosylated. {ECO:0000269|PubMed:18036614}.
PtmSulfated. {ECO:0000250}.
SimilarityBelongs to the glycosyl hydrolase 31 family. {ECO:0000305}.
SimilarityContains 2 P-type (trefoil) domains. {ECO:0000255|PROSITE-ProRule:PRU00779}.
Subcellular LocationApical cell membrane; Single-pass type II membrane protein. Note=Brush border.
SubunitMonomer.
Tissue SpecificityExpressed in small intestine, granulocyte, and kidney but not in salivary gland or pancreas.
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