MGP Database

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MGP003771

UniProt Annotations

Entry Information
Gene Namecholesterol 25-hydroxylase
Protein EntryCH25H_HUMAN
UniProt IDO95992
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCholesterol + AH(2) + O(2) = 25- hydroxycholesterol + A + H(2)O.
CofactorName=Fe cation; Xref=ChEBI:CHEBI:24875;
FunctionCatalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. {ECO:0000269|PubMed:9852097}.
PtmN-glycosylated. {ECO:0000269|PubMed:9852097}.
SimilarityBelongs to the sterol desaturase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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