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MGP003793

Record overview

MGPD IDMGP003793
Gene ID9076
SpeciesHomo sapiens (Human)
Gene Nameclaudin 1
Gene Symbol CLDN1
SynonymsCLD1; SEMP1; ILVASC;
Alternate namesclaudin-1; senescence-associated epithelial membrane protein 1;
Chromosome3
Map Location3q28-q29
SummaryTight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CLDN1

Proteins

claudin-1
Refseq ID:NP_066924
Protein GI:10863887
UniProt ID:O95832
mRNA ID:NM_021101
Length:211
RefSeq Status:
MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATV
GMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYP
KPAPSSGKDYV
 
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