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MGP003806

Record overview

MGPD IDMGP003806
Gene ID9128
SpeciesHomo sapiens (Human)
Gene Namepre-mRNA processing factor 4
Gene Symbol PRPF4
SynonymsPRP4; RP70; HPRP4; Prp4p; HPRP4P; SNRNP60;
Alternate namesU4/U6 small nuclear ribonucleoprotein Prp4; PRP4 homolog; PRP4 pre-mRNA processing factor 4 homolog; PRP4/STK/WD splicing factor; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4;
Chromosome9
Map Location9q31-q33
SummaryThe protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for PRPF4

Proteins

U4/U6 small nuclear ribonucleoprotein Prp4 isoform 1
Refseq ID:NP_004688
Protein GI:24431950
UniProt ID:O43172
mRNA ID:NM_004697
Length:522
RefSeq Status:
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQIN
VSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHK
EIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA
ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI
MFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDI
SSDGQLIATCSYDRTFKLWMAE
 
U4/U6 small nuclear ribonucleoprotein Prp4 isoform 2
Refseq ID:NP_001231855
Protein GI:349732206
UniProt ID:O43172
mRNA ID:NM_001244926
Length:521
RefSeq Status:
MASSRASSTATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINV
STDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKE
IPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAA
DGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIM
FLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDIS
SDGQLIATCSYDRTFKLWMAE
 
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