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MGP003809

UniProt Annotations

Entry Information
Gene Namecyclin E2
Protein EntryCCNE2_HUMAN
UniProt IDO96020
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=Long; IsoId=O96020-1; Sequence=Displayed; Name=Short; Synonyms=SV; IsoId=O96020-2; Sequence=VSP_001256;
FunctionEssential for the control of the cell cycle at the late G1 and early S phase.
InductionActivated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.
InteractionP24941:CDK2; NbExp=7; IntAct=EBI-375033, EBI-375096; P38936:CDKN1A; NbExp=2; IntAct=EBI-375033, EBI-375077; P46527:CDKN1B; NbExp=2; IntAct=EBI-375033, EBI-519280;
PtmPhosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway. {ECO:0000250}.
SimilarityBelongs to the cyclin family. Cyclin E subfamily. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:9840943}.
SubunitInteracts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.
Tissue SpecificityAccording to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne2/";
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