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MGP003816

UniProt Annotations

Entry Information
Gene Namesolute carrier family 28 (concentrative nucleoside transporter), member 1
Protein EntryS28A1_HUMAN
UniProt IDO00337
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00337-1; Sequence=Displayed; Name=2; IsoId=O00337-2; Sequence=VSP_037221, VSP_037222;
FunctionSodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.
PolymorphismThree variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity.
SimilarityBelongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. {ECO:0000305}.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityExpressed in kidney.
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