MGP Database

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MGP003822

Ontology/Pathway Information

Entrez Gene ID9181
Gene NameRho/Rac guanine nucleotide exchange factor (GEF) 2
Gene Symbol ARHGEF2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0016023 IEA:UniProtKB-SubCellCcytoplasmic membrane-bounded vesicle
GO:0005856 IDA:UniProtKBCcytoskeleton
GO:0005829 TAS:ReactomeCcytosol
GO:0043198 IEA:EnsemblCdendritic shaft
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0005794 IEA:UniProtKB-SubCellCGolgi apparatus
GO:0005874 IDA:UniProtKBCmicrotubule
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0043234 IDA:UniProtKBCprotein complex
GO:0032587 IDA:UniProtKBCruffle membrane
GO:0005819 IEA:UniProtKB-SubCellCspindle
GO:0005923 IEA:UniProtKB-SubCellCtight junction
GO:0031982 IDA:UniProtKBCvesicle
GO:0008017 IDA:UniProtKBFmicrotubule binding
GO:0048365 IDA:UniProtKBFRac GTPase binding
GO:0030676 IDA:UniProtKBFRac guanyl-nucleotide exchange factor activity
GO:0017048 IDA:UniProtKBFRho GTPase binding
GO:0005089 IDA:UniProtKBFRho guanyl-nucleotide exchange factor activity
GO:0008134 ISS:BHF-UCLFtranscription factor binding
GO:0008270 NAS:UniProtKBFzinc ion binding
GO:0007015 IMP:UniProtKBPactin filament organization
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0051301 IEA:UniProtKB-KWPcell division
GO:0000902 IMP:UniProtKBPcell morphogenesis
GO:0071474 ISS:BHF-UCLPcellular hyperosmotic response
GO:0071225 IDA:UniProtKBPcellular response to muramyl dipeptide
GO:0071356 ISS:BHF-UCLPcellular response to tumor necrosis factor
GO:0000132 IEA:EnsemblPestablishment of mitotic spindle orientation
GO:0045087 IEA:UniProtKB-KWPinnate immune response
GO:0006886 NAS:UniProtKBPintracellular protein transport
GO:0007067 IEA:UniProtKB-KWPmitotic nuclear division
GO:1902042 ISS:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902219 ISS:BHF-UCLPnegative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0007026 IMP:UniProtKBPnegative regulation of microtubule depolymerization
GO:0060546 ISS:BHF-UCLPnegative regulation of necroptotic process
GO:0050768 IEA:EnsemblPnegative regulation of neurogenesis
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0032755 IDA:UniProtKBPpositive regulation of interleukin-6 production
GO:0051092 IDA:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0050731 IDA:UniProtKBPpositive regulation of peptidyl-tyrosine phosphorylation
GO:0032855 IDA:GOCPpositive regulation of Rac GTPase activity
GO:0032321 IDA:GOCPpositive regulation of Rho GTPase activity
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032760 IDA:UniProtKBPpositive regulation of tumor necrosis factor production
GO:0042127 TAS:UniProtKBPregulation of cell proliferation
GO:0035023 NAS:UniProtKBPregulation of Rho protein signal transduction
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_18407G alpha (12/13) signalling events
REACT_19184GPCR downstream signaling
REACT_13638NRAGE signals death through JNK
REACT_13776p75 NTR receptor-mediated signalling
REACT_11051Rho GTPase cycle
REACT_14797Signaling by GPCR
REACT_11044Signaling by Rho GTPases
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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