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MGP003834

Record overview

MGPD IDMGP003834
Gene ID9227
SpeciesHomo sapiens (Human)
Gene Namelecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Gene Symbol LRAT
SynonymsLCA14;
Alternate nameslecithin retinol acyltransferase;
Chromosome4
Map Location4q32.1
EC Number2.3.1.135
SummaryThe protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
OrthologsView orthologs and multiple alignments for LRAT

Proteins

lecithin retinol acyltransferase precursor
Refseq ID:NP_004735
Protein GI:46249410
UniProt ID:O95237
mRNA ID:NM_004744
Length:230
RefSeq Status:
MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILG
VIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAV
LGLASIVCTGLVSYTTLPAIFIPFFLWMAG
 
sig_peptide: 1..31
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3337
peptide sequence: 
MKNPMLEVVSLLLEKLLLISNFTLFSSGAAG
 
lecithin retinol acyltransferase precursor
Refseq ID:NP_001288574
Protein GI:675022749
UniProt ID:O95237
mRNA ID:NM_001301645
Length:230
RefSeq Status:
Protein sequence is identical to GI:46249410 (mRNA isoform)
 
sig_peptide: 1..31
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3337
peptide sequence: 
MKNPMLEVVSLLLEKLLLISNFTLFSSGAAG

sig_peptide: 1..31
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 3337
peptide sequence: 
MKNPMLEVVSLLLEKLLLISNFTLFSSGAAG
 
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