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MGP Database

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MGP003841

UniProt Annotations

Entry Information

Gene Name	calcium channel, voltage-dependent, alpha 2/delta subunit 2
Protein Entry	CA2D2_HUMAN
UniProt ID	Q9NY47
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=Alpha2delta-2a; IsoId=Q9NY47-1; Sequence=Displayed; Name=2; Synonyms=Alpha2delta-2b; IsoId=Q9NY47-2; Sequence=VSP_028059; Name=3; IsoId=Q9NY47-3; Sequence=VSP_028059, VSP_028060; Name=4; IsoId=Q9NY47-4; Sequence=VSP_028058, VSP_028059, VSP_028060; Name=5; Synonyms=Alpha2delta-2c; IsoId=Q9NY47-5; Sequence=VSP_028060;
Domain	The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch. {ECO:0000250}.
Function	The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. {ECO:0000269\|PubMed:12555074, ECO:0000269\|PubMed:15111129}.
Miscellaneous	Binds gabapentin, an antiepileptic drug.
Ptm	May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity). {ECO:0000250}.
Similarity	Belongs to the calcium channel subunit alpha-2/delta family. {ECO:0000305}.
Similarity	Contains 1 cache domain. {ECO:0000305}.
Similarity	Contains 1 VWFA domain. {ECO:0000255\|PROSITE- ProRule:PRU00219}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000250}.
Subunit	Dimer formed of alpha-2-2 and delta-2 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity). {ECO:0000250}.
Tissue Specificity	Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain. {ECO:0000269\|PubMed:10766861, ECO:0000269\|PubMed:11687876, ECO:0000269\|PubMed:9880589}.