MGP Database

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MGP003844

Ontology/Pathway Information

Entrez Gene ID9261
Gene Namemitogen-activated protein kinase-activated protein kinase 2
Gene Symbol MAPKAPK2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:HPACcentrosome
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0004871 TAS:ProtIncFsignal transducer activity
GO:0070935 IDA:UniProtKBP3'-UTR-mediated mRNA stabilization
GO:0000187 TAS:ReactomePactivation of MAPK activity
GO:0019369 TAS:ReactomeParachidonic acid metabolic process
GO:0006974 IMP:UniProtKBPcellular response to DNA damage stimulus
GO:0035924 IMP:BHF-UCLPcellular response to vascular endothelial growth factor stimulus
GO:0031572 IMP:UniProtKBPG2 DNA damage checkpoint
GO:0010467 TAS:ReactomePgene expression
GO:0006954 ISS:UniProtKBPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0048839 IEA:EnsemblPinner ear development
GO:0006691 TAS:ReactomePleukotriene metabolic process
GO:0044351 ISS:UniProtKBPmacropinocytosis
GO:0000165 TAS:ProtIncPMAPK cascade
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0018105 IDA:BHF-UCLPpeptidyl-serine phosphorylation
GO:0006468 TAS:ProtIncPprotein phosphorylation
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:0032675 ISS:UniProtKBPregulation of interleukin-6 production
GO:0032680 IDA:UniProtKBPregulation of tumor necrosis factor production
GO:0034097 IDA:UniProtKBPresponse to cytokine
GO:0032496 ISS:UniProtKBPresponse to lipopolysaccharide
GO:0006950 IDA:UniProtKBPresponse to stress
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 ISS:UniProtKBPtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0048010 IMP:BHF-UCLPvascular endothelial growth factor receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_21399activated TAK1 mediates p38 MAPK activation
REACT_6890Activated TLR4 signalling
REACT_147851Arachidonic acid metabolism
REACT_24915Butyrate Response Factor 1 (BRF1) destabilizes mRNA
REACT_120956Cellular responses to stress
REACT_263897Cellular response to heat stress
REACT_169274Cellular Senescence
REACT_12524CREB phosphorylation
REACT_71Gene Expression
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12433Nuclear Events (kinase and transcription factor activation)
REACT_169436Oxidative Stress Induced Senescence
REACT_12065p38MAPK events
REACT_264487Regulation of HSF1-mediated heat shock response
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_150420Synthesis of Leukotrienes (LT) and Eoxins (EX)
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_25064Tristetraprolin (TTP) destabilizes mRNA
REACT_264464VEGFA-VEGFR2 Pathway
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