MGP Database

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MGP003858

Ontology/Pathway Information

Entrez Gene ID9314
Gene NameKruppel-like factor 4 (gut)
Gene Symbol KLF4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0000790 IDA:BHF-UCLCnuclear chromatin
GO:0005654 IDA:HPACnucleoplasm
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0000987 IDA:BHF-UCLFcore promoter proximal region sequence-specific DNA binding
GO:0003690 IEA:EnsemblFdouble-stranded DNA binding
GO:0035014 IEA:EnsemblFphosphatidylinositol 3-kinase regulator activity
GO:0001077 IMP:BHF-UCLFRNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 IPI:BHF-UCLFRNA polymerase II transcription factor binding
GO:0001190 IDA:BHF-UCLFRNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003700 NAS:UniProtKBFsequence-specific DNA binding transcription factor activity
GO:0001010 ISS:BHF-UCLFsequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0044212 ISS:UniProtKBFtranscription regulatory region DNA binding
GO:0008270 NAS:UniProtKBFzinc ion binding
GO:0071409 IEA:EnsemblPcellular response to cycloheximide
GO:0071363 IDA:BHF-UCLPcellular response to growth factor stimulus
GO:0070301 IEA:EnsemblPcellular response to hydrogen peroxide
GO:0071499 IMP:BHF-UCLPcellular response to laminar fluid shear stress
GO:1901653 IEA:EnsemblPcellular response to peptide
GO:0009913 IEA:EnsemblPepidermal cell differentiation
GO:0048730 IEA:EnsemblPepidermis morphogenesis
GO:0045444 ISS:BHF-UCLPfat cell differentiation
GO:0007500 TAS:ProtIncPmesodermal cell fate determination
GO:0090051 IDA:BHF-UCLPnegative regulation of cell migration involved in sprouting angiogenesis
GO:0008285 TAS:ProtIncPnegative regulation of cell proliferation
GO:2000342 IDA:BHF-UCLPnegative regulation of chemokine (C-X-C motif) ligand 2 production
GO:0043154 IDA:BHF-UCLPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0070373 IEA:EnsemblPnegative regulation of ERK1 and ERK2 cascade
GO:0034115 IDA:BHF-UCLPnegative regulation of heterotypic cell-cell adhesion
GO:0050728 TAS:BHF-UCLPnegative regulation of inflammatory response
GO:0045415 IDA:BHF-UCLPnegative regulation of interleukin-8 biosynthetic process
GO:0014740 IEA:EnsemblPnegative regulation of muscle hyperplasia
GO:0032088 IDA:BHF-UCLPnegative regulation of NF-kappaB transcription factor activity
GO:0014067 IEA:EnsemblPnegative regulation of phosphatidylinositol 3-kinase signaling
GO:0051898 IEA:EnsemblPnegative regulation of protein kinase B signaling
GO:0060761 IDA:BHF-UCLPnegative regulation of response to cytokine stimulus
GO:0048662 IEA:EnsemblPnegative regulation of smooth muscle cell proliferation
GO:0045892 IDA:UniProtKBPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0032270 IMP:BHF-UCLPpositive regulation of cellular protein metabolic process
GO:0046985 IMP:BHF-UCLPpositive regulation of hemoglobin biosynthetic process
GO:0045429 IMP:BHF-UCLPpositive regulation of nitric oxide biosynthetic process
GO:0051247 IGI:BHF-UCLPpositive regulation of protein metabolic process
GO:0051973 IDA:BHF-UCLPpositive regulation of telomerase activity
GO:0045893 ISS:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IMP:BHF-UCLPpositive regulation of transcription from RNA polymerase II promoter
GO:0031077 IEA:EnsemblPpost-embryonic camera-type eye development
GO:0035166 IMP:BHF-UCLPpost-embryonic hemopoiesis
GO:0045595 ISS:UniProtKBPregulation of cell differentiation
GO:0032526 IEA:EnsemblPresponse to retinoic acid
GO:0019827 ISS:UniProtKBPstem cell maintenance
GO:0006366 ISS:BHF-UCLPtranscription from RNA polymerase II promoter
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111045Developmental Biology
REACT_17015Metabolism of proteins
REACT_160078Peptide hormone metabolism
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
REACT_263856Transcriptional regulation of pluripotent stem cells
REACT_27161Transcriptional regulation of white adipocyte differentiation
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