MGP Database

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MGP003865

UniProt Annotations

Entry Information
Gene NameUDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
Protein EntryB4GT6_HUMAN
UniProt IDQ9UBX8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UBX8-1; Sequence=Displayed; Name=2; IsoId=Q9UBX8-2; Sequence=VSP_056554; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=3 uM for glucosylceramide {ECO:0000269|PubMed:3099851}; KM=0.5 uM for UDP-galactose {ECO:0000269|PubMed:3099851}; Vmax=0.06 nmol/h/mg enzyme toward glucosylceramide {ECO:0000269|PubMed:3099851}; Vmax=86 nmol/h/mg enzyme toward UDP-galactose {ECO:0000269|PubMed:3099851};
Catalytic ActivityUDP-alpha-D-galactose + beta-D-glucosyl- (1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide.
Catalytic ActivityUDP-galactose + glucosylceramide = UDP + lactosylceramide.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:3099851}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:3099851};
Enzyme RegulationInhibited by EDTA. {ECO:0000250}.
FunctionRequired for the biosynthesis of glycosphingolipids. {ECO:0000269|PubMed:1551920, ECO:0000269|PubMed:3099851}.
PathwayProtein modification; protein glycosylation.
SimilarityBelongs to the glycosyltransferase 7 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack.
Tissue SpecificityHigh expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Beta-1,4-galactosyltransferase 6; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_441";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B4GALT6";
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