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MGP003876

UniProt Annotations

Entry Information
Gene Namesolute carrier family 22 (organic anion transporter), member 6
Protein EntryS22A6_HUMAN
UniProt IDQ4U2R8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=OAT1-1; IsoId=Q4U2R8-1; Sequence=Displayed; Name=2; Synonyms=OAT1-2; IsoId=Q4U2R8-2; Sequence=VSP_032169; Name=3; Synonyms=OAT1-3; IsoId=Q4U2R8-3; Sequence=VSP_032168, VSP_032169; Note=No experimental confirmation available.; Name=4; Synonyms=OAT1-4; IsoId=Q4U2R8-4; Sequence=VSP_032168; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=9.3 uM for PAH (isoform 1) {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=4 uM for PAH (isoform 2) {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=11 uM for edaravone {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=46 uM for cidofovir {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=30 uM for adefovir {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=5.77 uM for 2,4-D {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=23.5 uM for HA {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=14 uM for IA {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=20.5 uM for IS {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; KM=141 uM for CMPF {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=534 pmol/min/mg enzyme for 2,4-D uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=430 pmol/min/mg enzyme for HA uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=110 pmol/min/mg enzyme for IA uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=216 pmol/min/mg enzyme for IS uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473}; Vmax=801 pmol/min/mg enzyme for CMPF uptake {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15846473};
DomainMultiple cysteine residues are necessary for proper targeting to the plasma membrane. {ECO:0000250}.
FunctionInvolved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate. {ECO:0000250, ECO:0000269|PubMed:12538807, ECO:0000269|PubMed:15644426, ECO:0000269|PubMed:17038320, ECO:0000269|PubMed:17502342, ECO:0000269|PubMed:9762842, ECO:0000269|PubMed:9887087}.
InteractionQ92624:APPBP2; NbExp=3; IntAct=EBI-749741, EBI-743771;
PtmGlycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane. {ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:14749323}.
SimilarityBelongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityStrongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO:0000269|PubMed:10049739, ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}.
Web ResourceName=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/slc22a6/";
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