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MGP003886

Record overview

MGPD IDMGP003886
Gene ID9402
SpeciesHomo sapiens (Human)
Gene NameGRB2-related adaptor protein 2
Gene Symbol GRAP2
SynonymsP38; GADS; GRID; GRPL; GrbX; Mona; GRB2L; GRBLG; Grf40; GRAP-2;
Alternate namesGRB2-related adapter protein 2; GRB-2-like protein; GRB2-related protein with insert domain; SH3-SH2-SH3 adapter Mona; SH3-SH2-SH3 adaptor molecule; adapter protein GRID; grf-40; grf40 adapter protein; growth factor receptor-binding protein; growth factor receptor-bound protein 2-related adaptor protein 2; hematopoietic cell-associated adapter protein GrpL; hematopoietic cell-associated adaptor protein GRPL;
Chromosome22
Map Location22q13.2
SummaryThis gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
OrthologsView orthologs and multiple alignments for GRAP2

Proteins

GRB2-related adapter protein 2 isoform 1
Refseq ID:NP_004801
Protein GI:4758476
UniProt ID:O75791
mRNA ID:NM_004810
Length:330
RefSeq Status:
MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHED
DVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQH
QPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEV
LDSSNPSWWTGRLHNKLGLFPANYVAPMTR
 
GRB2-related adapter protein 2 isoform 1
Refseq ID:NP_001278753
Protein GI:625180311
UniProt ID:O75791
mRNA ID:NM_001291824
Length:330
RefSeq Status:
Protein sequence is identical to GI:4758476 (mRNA isoform)
 
GRB2-related adapter protein 2 isoform 1
Refseq ID:NP_001278754
Protein GI:625180309
UniProt ID:O75791
mRNA ID:NM_001291825
Length:330
RefSeq Status:
Protein sequence is identical to GI:4758476 (mRNA isoform)
 
GRB2-related adapter protein 2 isoform 2
Refseq ID:NP_001278755
Protein GI:625180314
UniProt ID:B7Z8E3
mRNA ID:NM_001291826
Length:258
RefSeq Status:
MGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSG
AVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGR
VRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR
 
GRB2-related adapter protein 2 isoform 3
Refseq ID:NP_001278757
Protein GI:625180318
UniProt ID:O75791
mRNA ID:NM_001291828
Length:217
RefSeq Status:
MVSRRPLSTPGRELTHGQGGWLLHHPGQPELPRGLLHLCQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQ
LQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRL
HNKLGLFPANYVAPMTR
 
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