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MGP003891

Record overview

MGPD IDMGP003891
Gene ID9415
SpeciesHomo sapiens (Human)
Gene Namefatty acid desaturase 2
Gene Symbol FADS2
SynonymsD6D; DES6; TU13; FADSD6; LLCDL2; SLL0262;
Alternate namesfatty acid desaturase 2; delta(6) desaturase; delta(6) fatty acid desaturase; delta-6 desaturase; delta-6 fatty acid desaturase; delta-6-desaturase; linoleoyl-CoA desaturase (delta-6-desaturase)-like 2;
Chromosome11
Map Location11q12.2
EC Number1.14.19.-
SummaryThe protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
OrthologsView orthologs and multiple alignments for FADS2

Proteins

fatty acid desaturase 2 isoform 1
Refseq ID:NP_004256
Protein GI:4758334
UniProt ID:O95864
mRNA ID:NM_004265
Length:444
RefSeq Status:
MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPS
QDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKF
VIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAV
SYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIA
PLVKSLCAKHGIEYQEKPLLRALLDIIRSLKKSGKLWLDAYLHK
 
fatty acid desaturase 2 isoform 2 precursor
Refseq ID:NP_001268430
Protein GI:527498295
UniProt ID:O95864
mRNA ID:NM_001281501
Length:422
RefSeq Status:
MHGREAGPFVCVCVLLASIPTPQTPLLQASLPPFHPASAGHPITGQQDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAED
MNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHA
KPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLF
LNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRA
LLDIIRSLKKSGKLWLDAYLHK
 
sig_peptide: 1..4
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 500
peptide sequence: 
MHGR
 
fatty acid desaturase 2 isoform 3
Refseq ID:NP_001268431
Protein GI:527498297
UniProt ID:O95864
mRNA ID:NM_001281502
Length:413
RefSeq Status:
MTREPPGCRRVNSLMLYTLRSITSHRSSHPERWATSSQDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHV
FFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDP
DVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLES
HWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSLK
KSGKLWLDAYLHK
 
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