MGP Database

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MGP003907

Ontology/Pathway Information

Entrez Gene ID9447
Gene Nameabsent in melanoma 2
Gene Symbol AIM2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0097169 IDA:UniProtKBCAIM2 inflammasome complex
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IEA:UniProtKB-SubCellCnucleus
GO:0003690 IDA:UniProtKBFdouble-stranded DNA binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0002218 IDA:UniProtKBPactivation of innate immune response
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0035690 IDA:MGIPcellular response to drug
GO:0035458 IEA:EnsemblPcellular response to interferon-beta
GO:0006955 TAS:ProtIncPimmune response
GO:0006954 IEA:UniProtKB-KWPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0050702 IMP:MGIPinterleukin-1 beta secretion
GO:0032088 IDA:UniProtKBPnegative regulation of NF-kappaB transcription factor activity
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:2001056 IDA:UniProtKBPpositive regulation of cysteine-type endopeptidase activity
GO:0002230 ISS:UniProtKBPpositive regulation of defense response to virus by host
GO:0032731 IDA:UniProtKBPpositive regulation of interleukin-1 beta production
GO:0050718 IDA:UniProtKBPpositive regulation of interleukin-1 beta secretion
GO:0051092 IDA:UniProtKBPpositive regulation of NF-kappaB transcription factor activity
GO:0032461 IDA:UniProtKBPpositive regulation of protein oligomerization
GO:0070269 IDA:UniProtKBPpyroptosis
GO:0033209 IDA:UniProtKBPtumor necrosis factor-mediated signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6900Immune System
REACT_75900Inflammasomes
REACT_6802Innate Immune System
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75777The AIM2 inflammasome
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