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MGP003908

UniProt Annotations

Entry Information
Gene Namemitogen-activated protein kinase kinase kinase kinase 4
Protein EntryM4K4_HUMAN
UniProt IDO95819
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1 {ECO:0000269|PubMed:9890973}; Synonyms=Tumor-associated; IsoId=O95819-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:9890973}; IsoId=O95819-2; Sequence=VSP_007054, VSP_007057; Name=3 {ECO:0000269|PubMed:9890973}; IsoId=O95819-3; Sequence=VSP_007056, VSP_007057; Note=Variant in position: 682:D->V.; Name=4 {ECO:0000269|PubMed:9890973}; Synonyms=HGK-S {ECO:0000269|PubMed:9890973}; IsoId=O95819-4; Sequence=VSP_007054, VSP_007055, VSP_007057, VSP_007058; Name=5 {ECO:0000269|PubMed:9890973}; Synonyms=HGK-L {ECO:0000269|PubMed:9890973}; IsoId=O95819-5; Sequence=VSP_007054, VSP_007055, VSP_007056, VSP_007057, VSP_007058;
Catalytic ActivityATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:9890973}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:9890973};
FunctionSerine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:9890973}.
InteractionQ9H0R5:GBP3; NbExp=4; IntAct=EBI-2511133, EBI-2798916;
SimilarityBelongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. {ECO:0000305}.
SimilarityContains 1 CNH domain. {ECO:0000255|PROSITE- ProRule:PRU00795, ECO:0000305}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:14966141}.
SubunitInteracts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially). {ECO:0000250, ECO:0000269|PubMed:12387898, ECO:0000269|PubMed:14966141}.
Tissue SpecificityAppears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. {ECO:0000269|PubMed:9890973}.
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