MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003909

UniProt Annotations

Entry Information
Gene Namelymphocyte antigen 86
Protein EntryLY86_HUMAN
UniProt IDO95711
SpeciesHuman
Comments
Comment typeDescription
FunctionMay cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). {ECO:0000250}.
InductionIn monocytes, down-regulated by the cell-wall fraction of Mycobacterium bovis (BCG-CWS).
Sequence CautionSequence=BAA76410.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Subcellular LocationSecreted, extracellular space. Note=Associated with CD180 at the cell surface.
SubunitM-shaped tetramer of two CD180-LY86 heterodimers. {ECO:0000269|PubMed:21959264}.
Tissue SpecificityHighly expressed in B-cells, monocytes and tonsil.
  logo