MGP Database

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MGP003912

Ontology/Pathway Information

Entrez Gene ID9459
Gene NameRac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Gene Symbol ARHGEF6
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0005829 TAS:ReactomeCcytosol
GO:0005622 IC:UniProtKBCintracellular
GO:0030027 ISS:UniProtKBClamellipodium
GO:0005096 NAS:UniProtKBFGTPase activator activity
GO:0005089 NAS:UniProtKBFRho guanyl-nucleotide exchange factor activity
GO:0006915 NAS:UniProtKBPapoptotic process
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0034329 TAS:ReactomePcell junction assembly
GO:0007254 NAS:UniProtKBPJNK cascade
GO:0030032 ISS:UniProtKBPlamellipodium assembly
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0043547 NAS:GOCPpositive regulation of GTPase activity
GO:0032321 NAS:GOCPpositive regulation of Rho GTPase activity
GO:0051056 TAS:ReactomePregulation of small GTPase mediated signal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111155Cell-Cell communication
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_20649Cell-extracellular matrix interactions
REACT_20676Cell junction organization
REACT_18407G alpha (12/13) signalling events
REACT_19184GPCR downstream signaling
REACT_13638NRAGE signals death through JNK
REACT_13776p75 NTR receptor-mediated signalling
REACT_20580Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
REACT_11051Rho GTPase cycle
REACT_14797Signaling by GPCR
REACT_11044Signaling by Rho GTPases
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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