MGP Database

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MGP003921

UniProt Annotations

Entry Information
Gene Namephosphatidylglycerophosphate synthase 1
Protein EntryPGPS1_HUMAN
UniProt IDQ32NB8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q32NB8-1; Sequence=Displayed; Name=2; IsoId=Q32NB8-2; Sequence=VSP_033899, VSP_033902, VSP_033903; Name=3; IsoId=Q32NB8-3; Sequence=VSP_033900, VSP_033901; Note=No experimental confirmation available.; Name=4; IsoId=Q32NB8-4; Sequence=VSP_033897, VSP_033898; Note=No experimental confirmation available.;
Catalytic ActivityCDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Enzyme RegulationActivated by calcium and magnesium and inhibited by other bivalent cations. {ECO:0000250}.
FunctionFunctions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}.
PathwayPhospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Sequence CautionSequence=AAH08903.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15570.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH35662.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH35662.1; Type=Frameshift; Positions=420; Evidence={ECO:0000305}; Sequence=BAB14921.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
SimilarityBelongs to the CDP-alcohol phosphatidyltransferase class-II family. {ECO:0000305}.
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular LocationMitochondrion {ECO:0000250}.
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