MGP Database

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MGP003923

UniProt Annotations

Entry Information
Gene Namekinesin family member 23
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q02241-1; Sequence=Displayed; Name=2; IsoId=Q02241-2; Sequence=VSP_021801; Name=3; IsoId=Q02241-3; Sequence=VSP_057348, VSP_057349, VSP_021801; Note=No experimental confirmation available.;
FunctionComponent of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. {ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:22522702}.
InteractionP62330:ARF6; NbExp=23; IntAct=EBI-306852, EBI-638181; P62331:Arf6 (xeno); NbExp=10; IntAct=EBI-306852, EBI-988682; Q9NR09:BIRC6; NbExp=4; IntAct=EBI-306852, EBI-1765160; Q9H0H5:RACGAP1; NbExp=10; IntAct=EBI-306852, EBI-717233; P63104:YWHAZ; NbExp=5; IntAct=EBI-306852, EBI-347088;
PtmUbiquitinated. Deubiquitinated by USP8/UBPY. {ECO:0000269|PubMed:18329369}.
SimilarityBelongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. {ECO:0000255|PROSITE- ProRule:PRU00283}.
SimilarityContains 1 kinesin motor domain. {ECO:0000255|PROSITE- ProRule:PRU00283}.
Subcellular LocationNucleus. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to the interzone of mitotic spindles. Detected at the midbody during later stages of mitotic cytokinesis.
SubunitHeterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex composed of RACGAP1 and KIF23. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1. Interacts with ANXA11 during cytokinesis. Interacts with BIRC6/bruce and USP8/UBPY. Interacts with ARF6, forming heterodimers and heterotetramers. {ECO:0000269|PubMed:11782313, ECO:0000269|PubMed:15197175, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:16103226, ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:18329369, ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:22522702}.
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