MGP Database

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MGP003929

UniProt Annotations

Entry Information
Gene NameADAM metallopeptidase with thrombospondin type 1 motif, 3
Protein EntryATS3_HUMAN
UniProt IDO15072
SpeciesHuman
Comments
Comment typeDescription
CautionHas sometimes been referred to as ADAMTS4. {ECO:0000305}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
DomainThe spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
FunctionCleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.
PtmGlycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)- (S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W- X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). {ECO:0000250}.
PtmThe precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
SimilarityContains 1 disintegrin domain. {ECO:0000305}.
SimilarityContains 1 peptidase M12B domain. {ECO:0000255|PROSITE-ProRule:PRU00276}.
SimilarityContains 1 PLAC domain. {ECO:0000255|PROSITE- ProRule:PRU00233}.
SimilarityContains 4 TSP type-1 domains. {ECO:0000255|PROSITE- ProRule:PRU00210}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue SpecificityFound in cartilage and skin.
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