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MGP003954

UniProt Annotations

Entry Information
Gene Nameprotein disulfide isomerase family A, member 4
Protein EntryPDIA4_HUMAN
UniProt IDP13667
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCatalyzes the rearrangement of -S-S- bonds in proteins.
CautionWas originally thought to be a deoxycytidine kinase. {ECO:0000305|PubMed:2549034}.
InteractionQ76353:- (xeno); NbExp=3; IntAct=EBI-1054653, EBI-6248077; P23284:PPIB; NbExp=3; IntAct=EBI-1054653, EBI-8771982;
SimilarityBelongs to the protein disulfide isomerase family. {ECO:0000305}.
SimilarityContains 3 thioredoxin domains. {ECO:0000255|PROSITE- ProRule:PRU00691}.
Subcellular LocationEndoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SubunitPart of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
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