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MGP003958

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family G (WHITE), member 1
Protein EntryABCG1_HUMAN
UniProt IDP45844
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P45844-1; Sequence=Displayed; Name=2; Synonyms=J; IsoId=P45844-2; Sequence=VSP_000047, VSP_000051; Name=3; Synonyms=ABDE; IsoId=P45844-3; Sequence=VSP_000048, VSP_000051; Name=4; Synonyms=G; IsoId=P45844-4; Sequence=VSP_000051; Name=5; Synonyms=F; IsoId=P45844-5; Sequence=VSP_000049, VSP_000051; Name=6; Synonyms=HI; IsoId=P45844-6; Sequence=VSP_000046, VSP_000051; Name=7; Synonyms=C; IsoId=P45844-7; Sequence=VSP_000050, VSP_000051; Name=8; IsoId=P45844-8; Sequence=VSP_010718;
FunctionTransporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
InductionStrongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repressed by ZNF202. {ECO:0000269|PubMed:10639163, ECO:0000269|PubMed:10799558, ECO:0000269|PubMed:11279031, ECO:0000269|PubMed:12032171}.
InteractionQ9H172:ABCG4; NbExp=2; IntAct=EBI-8584087, EBI-8584118;
MiscellaneousA protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells. {ECO:0000305|PubMed:22042635}.
PtmPalmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. {ECO:0000269|PubMed:23388354}.
Sequence CautionSequence=AAC51098.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK28841.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA95530.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB13728.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA62631.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC00730.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.
SimilarityContains 1 ABC transmembrane type-2 domain. {ECO:0000305}.
SimilarityContains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:22042635}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269|PubMed:22042635}. Golgi apparatus membrane {ECO:0000269|PubMed:22042635}; Multi-pass membrane protein {ECO:0000269|PubMed:22042635}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
SubunitMay form heterodimers with several heterologous partners of the ABCG subfamily.
Tissue SpecificityExpressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease. {ECO:0000269|PubMed:11350058}.
Web ResourceName=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P45844";
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