MGP Database

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MGP003966

Ontology/Pathway Information

Entrez Gene ID9641
Gene Nameinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Gene Symbol IKBKE
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0010008 TAS:ReactomeCendosome membrane
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0016605 IDA:UniProtKBCPML body
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0008384 IEA:UniProtKB-ECFIkappaB kinase activity
GO:0004704 IDA:UniProtKBFNF-kappaB-inducing kinase activity
GO:0006955 NAS:UniProtKBPimmune response
GO:0045087 TAS:ReactomePinnate immune response
GO:0008630 IMP:UniProtKBPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0032480 TAS:ReactomePnegative regulation of type I interferon production
GO:0038061 IDA:GOCPNIK/NF-kappaB signaling
GO:0043123 IEP:UniProtKBPpositive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_25148Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_6809MyD88-independent cascade
REACT_25271Negative regulators of RIG-I/MDA5 signaling
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_25026TRAF3-dependent IRF activation pathway
REACT_24938TRAF6 mediated IRF7 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
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