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MGP003982

UniProt Annotations

Entry Information
Gene Nameubiquitin protein ligase E3C
Protein EntryUBE3C_HUMAN
UniProt IDQ15386
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q15386-1; Sequence=Displayed; Name=2; IsoId=Q15386-2; Sequence=VSP_013956, VSP_013957; Note=No experimental confirmation available.; Name=3; IsoId=Q15386-3; Sequence=VSP_013953, VSP_013954, VSP_013955; Note=No experimental confirmation available.;
DomainThe C-terminal is necessary and sufficient for the poly- ubiquitin chain assembly.
FunctionE3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:16341092, ECO:0000269|PubMed:16601690}.
MiscellaneousA cysteine residue is required for ubiquitin- thioester formation.
PathwayProtein modification; protein ubiquitination.
Sequence CautionSequence=BAA02799.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. {ECO:0000255|PROSITE-ProRule:PRU00104}.
SimilarityContains 1 IQ domain. {ECO:0000255|PROSITE- ProRule:PRU00116}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitInteracts with 26S proteasomes. Interacts (via the N- terminal) with CAND2; the interaction stimulates ubiquitination of CAND2 in vitro. May interact (via the HECT domain) with UBE2D1 and, less efficiently, with UBE2L3. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:9575161}.
Tissue SpecificityHighly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. {ECO:0000269|PubMed:11278995, ECO:0000269|PubMed:12692129, ECO:0000269|PubMed:9575161}.
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