MGP Database

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MGP003983

Ontology/Pathway Information

Entrez Gene ID9693
Gene NameRap guanine nucleotide exchange factor (GEF) 2
Gene Symbol RAPGEF2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 ISS:UniProtKBCcell-cell junction
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005887 NAS:UniProtKBCintegral component of plasma membrane
GO:0005770 IDA:UniProtKBClate endosome
GO:0016020 IDA:UniProtKBCmembrane
GO:0043025 ISS:UniProtKBCneuronal cell body
GO:0043005 ISS:UniProtKBCneuron projection
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005886 ISS:UniProtKBCplasma membrane
GO:0043234 ISS:UniProtKBCprotein complex
GO:0045202 ISS:UniProtKBCsynapse
GO:0031697 IDA:UniProtKBFbeta-1 adrenergic receptor binding
GO:0005509 NAS:UniProtKBFcalcium ion binding
GO:0030552 IDA:UniProtKBFcAMP binding
GO:0019992 NAS:UniProtKBFdiacylglycerol binding
GO:0030165 IDA:UniProtKBFPDZ domain binding
GO:0046582 IDA:UniProtKBFRap GTPase activator activity
GO:0017034 IDA:UniProtKBFRap guanyl-nucleotide exchange factor activity
GO:0005088 IDA:UniProtKBFRas guanyl-nucleotide exchange factor activity
GO:0004871 TAS:UniProtKBFsignal transducer activity
GO:0050699 IDA:UniProtKBFWW domain binding
GO:0071880 IDA:UniProtKBPadenylate cyclase-activating adrenergic receptor signaling pathway
GO:0001568 ISS:UniProtKBPblood vessel development
GO:0031547 ISS:UniProtKBPbrain-derived neurotrophic factor receptor signaling pathway
GO:0019933 IDA:UniProtKBPcAMP-mediated signaling
GO:0071320 IDA:UniProtKBPcellular response to cAMP
GO:0071321 IDA:UniProtKBPcellular response to cGMP
GO:1990090 ISS:UniProtKBPcellular response to nerve growth factor stimulus
GO:0061028 IMP:UniProtKBPestablishment of endothelial barrier
GO:0021884 ISS:UniProtKBPforebrain neuron development
GO:0007186 IDA:UniProtKBPG-protein coupled receptor signaling pathway
GO:0035556 TAS:UniProtKBPintracellular signal transduction
GO:0000165 NAS:UniProtKBPMAPK cascade
GO:0008285 IDA:UniProtKBPnegative regulation of cell proliferation
GO:0050774 IDA:UniProtKBPnegative regulation of dendrite morphogenesis
GO:0048022 ISS:UniProtKBPnegative regulation of melanin biosynthetic process
GO:0038180 ISS:UniProtKBPnerve growth factor signaling pathway
GO:0001764 ISS:UniProtKBPneuron migration
GO:0031175 IDA:UniProtKBPneuron projection development
GO:0007218 IDA:UniProtKBPneuropeptide signaling pathway
GO:2000481 IDA:UniProtKBPpositive regulation of cAMP-dependent protein kinase activity
GO:0043950 IDA:UniProtKBPpositive regulation of cAMP-mediated signaling
GO:2000670 IDA:UniProtKBPpositive regulation of dendritic cell apoptotic process
GO:0070374 IDA:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:2001224 ISS:UniProtKBPpositive regulation of neuron migration
GO:0010976 ISS:UniProtKBPpositive regulation of neuron projection development
GO:0032092 ISS:UniProtKBPpositive regulation of protein binding
GO:0045860 IDA:UniProtKBPpositive regulation of protein kinase activity
GO:0032854 IDA:UniProtKBPpositive regulation of Rap GTPase activity
GO:0032320 IDA:UniProtKBPpositive regulation of Ras GTPase activity
GO:2001214 ISS:UniProtKBPpositive regulation of vasculogenesis
GO:0032486 IMP:UniProtKBPRap protein signal transduction
GO:1901888 IMP:UniProtKBPregulation of cell junction assembly
GO:0048167 ISS:UniProtKBPregulation of synaptic plasticity
GO:0007264 TAS:UniProtKBPsmall GTPase mediated signal transduction
GO:0021591 ISS:UniProtKBPventricular system development
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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