MGP Database

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MGP003988

UniProt Annotations

Entry Information
Gene Namehomocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Protein EntryHERP1_HUMAN
UniProt IDQ15011
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q15011-1; Sequence=Displayed; Name=2; IsoId=Q15011-2; Sequence=VSP_006708; Name=3; IsoId=Q15011-3; Sequence=VSP_006708, VSP_006709; Name=4; IsoId=Q15011-4; Sequence=VSP_047333; Note=No experimental confirmation available.;
FunctionComponent of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. {ECO:0000269|PubMed:16289116}.
InductionUp-regulated by endoplasmic reticulum stress and CREB3. {ECO:0000269|PubMed:10922362, ECO:0000269|PubMed:16940180}.
MiscellaneousAlthough the precise topology is not known, experimental data suggest that both the N- and C-termini face the cytosol.
SimilarityContains 1 ubiquitin-like domain. {ECO:0000255|PROSITE-ProRule:PRU00214}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:10922362}; Multi-pass membrane protein {ECO:0000269|PubMed:10922362}.
SubunitInteracts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6. {ECO:0000269|PubMed:11799129, ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:18656546}.
Tissue SpecificityWidely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
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