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MGP003993

UniProt Annotations

Entry Information
Gene Namededicator of cytokinesis 4
Protein EntryDOCK4_HUMAN
UniProt IDQ8N1I0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N1I0-1; Sequence=Displayed; Name=2; IsoId=Q8N1I0-2; Sequence=VSP_007703, VSP_007706; Note=No experimental confirmation available.; Name=3; IsoId=Q8N1I0-3; Sequence=VSP_007703; Note=No experimental confirmation available.; Name=4; IsoId=Q8N1I0-4; Sequence=VSP_007701, VSP_007705; Note=No experimental confirmation available.;
DomainThe DHR-2 domain probably mediates the GEF activity. {ECO:0000250}.
FunctionInvolved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:20679435}.
MiscellaneousInjection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.
Sequence CautionSequence=BAC03696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the DOCK family. {ECO:0000305}.
SimilarityContains 1 DHR-1 domain. {ECO:0000305}.
SimilarityContains 1 DHR-2 domain. {ECO:0000305}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationEndomembrane system; Peripheral membrane protein. Cytoplasm, cytosol.
SubunitInteracts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2. {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:19807924, ECO:0000269|PubMed:20679435}.
Tissue SpecificityWidely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. {ECO:0000269|PubMed:12628187}.
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