MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP003997

UniProt Annotations

Entry Information
Gene Namecentriolar coiled coil protein 110kDa
Protein EntryCP110_HUMAN
UniProt IDO43303
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O43303-1; Sequence=Displayed; Name=2; IsoId=O43303-2; Sequence=VSP_011897;
FunctionNecessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064}.
InductionUp-regulated during the transition from G1 to S phase of the cell cycle. The highest levels are observed in S phase, after which the levels decrease markedly. {ECO:0000269|PubMed:12361598}.
InteractionP62158:CALM3; NbExp=9; IntAct=EBI-1566217, EBI-397435; P41002:CCNF; NbExp=3; IntAct=EBI-1566217, EBI-1207574; Q8IW35:CEP97; NbExp=18; IntAct=EBI-1566217, EBI-1566210; P41208:CETN2; NbExp=3; IntAct=EBI-1566217, EBI-1789926; Q5T7B8:KIF24; NbExp=9; IntAct=EBI-1566217, EBI-2556811; Q96JN8:NEURL4; NbExp=9; IntAct=EBI-1566217, EBI-1053406;
PtmPhosphorylated by CDKs. {ECO:0000269|PubMed:12361598}.
PtmUbiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. {ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:23486064}.
Sequence CautionSequence=BAA24849.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Subcellular LocationCytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:21620453}. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.
SubunitInteracts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome- dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles. Interacts with USP20 and USP33. {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:19460342, ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691, ECO:0000269|PubMed:23486064}.
Tissue SpecificityHighly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:12361598}.
  logo