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MGP004018

Record overview

MGPD IDMGP004018
Gene ID9817
SpeciesHomo sapiens (Human)
Gene Namekelch-like ECH-associated protein 1
Gene Symbol KEAP1
SynonymsINrf2; KLHL19;
Alternate nameskelch-like ECH-associated protein 1; cytosolic inhibitor of Nrf2; kelch-like family member 19; kelch-like protein 19;
Chromosome19
Map Location19p13.2
SummaryThis gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for KEAP1

Proteins

kelch-like ECH-associated protein 1
Refseq ID:NP_036421
Protein GI:22027642
UniProt ID:Q14145
mRNA ID:NM_012289
Length:624
RefSeq Status:
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVL
ASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELH
QRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMT
NQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI
TAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
 
kelch-like ECH-associated protein 1
Refseq ID:NP_987096
Protein GI:45269145
UniProt ID:Q14145
mRNA ID:NM_203500
Length:624
RefSeq Status:
Protein sequence is identical to GI:22027642 (mRNA isoform)
 
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