MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP004024

UniProt Annotations

Entry Information
Gene Nametripartite motif containing 14
Protein EntryTRI14_HUMAN
UniProt IDQ14142
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=Alpha; IsoId=Q14142-1; Sequence=Displayed; Name=Beta; IsoId=Q14142-2; Sequence=VSP_000510, VSP_000511; Name=3; IsoId=Q14142-3; Sequence=VSP_044099; Name=4; IsoId=Q14142-4; Sequence=VSP_044097, VSP_044098, VSP_044099; Note=Ref.3 (BAC05071) sequence is in conflict in positions: 106:LKS->PIA. {ECO:0000305};
DomainThe B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation. {ECO:0000250}.
FunctionInhibits the transcriptional activity of SPI1 in a dose- dependent manner. {ECO:0000250}.
InductionBy interferons alpha and gamma. {ECO:0000269|PubMed:22711689}.
SimilarityBelongs to the TRIM/RBCC family. {ECO:0000305}.
SimilarityContains 1 B30.2/SPRY domain. {ECO:0000255|PROSITE- ProRule:PRU00548}.
SimilarityContains 1 B box-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00024}.
SubunitInteracts with SPI1. {ECO:0000250}.
Tissue SpecificityHighest expression in liver; undetectable in skeletal muscle.
  logo