MGP Database

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MGP004025

UniProt Annotations

Entry Information
Gene NameGINS complex subunit 1 (Psf1 homolog)
Protein EntryPSF1_HUMAN
UniProt IDQ14691
SpeciesHuman
Comments
Comment typeDescription
FunctionThe GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. GINS1 is essential for function. {ECO:0000269|PubMed:17417653}.
InductionSignificantly up-regulated in aggressive melanomas. {ECO:0000269|PubMed:17611626}.
Mass SpectrometryMass=98373; Mass_error=13; Method=Electrospray; Range=1-196; Note=This is the measured mass for the GINS complex.; Evidence={ECO:0000269|PubMed:17557111};
Sequence CautionSequence=BAA11503.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the GINS1/PSF1 family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}.
SubunitComponent of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:17545466, ECO:0000269|PubMed:17557111, ECO:0000269|PubMed:17652513}.
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