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MGP004026

UniProt Annotations

Entry Information
Gene Namehephaestin
Protein EntryHEPH_HUMAN
UniProt IDQ9BQS7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9BQS7-1; Sequence=Displayed; Name=2; IsoId=Q9BQS7-2; Sequence=VSP_011627; Name=3; IsoId=Q9BQS7-3; Sequence=VSP_047331; Note=No experimental confirmation available.; Name=4; IsoId=Q9BQS7-4; Sequence=VSP_047332; Note=No experimental confirmation available.;
CofactorName=Cu cation; Xref=ChEBI:CHEBI:23378; Evidence={ECO:0000250}; Note=Binds 6 Cu cations per monomer. {ECO:0000250};
FunctionMay function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
Sequence CautionSequence=AAQ89349.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAX05385.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAX05388.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the multicopper oxidase family. {ECO:0000305}.
SimilarityContains 6 plastocyanin-like domains. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue SpecificityDetected in breast, colon, bone trabecular cells and fibroblasts.
Web ResourceName=Wikipedia; Note=Hephaestin entry; URL="http://en.wikipedia.org/wiki/Hephaestin";
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