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MGP004029

UniProt Annotations

Entry Information
Gene NameC2 calcium-dependent domain containing 5
Protein EntryC2CD5_HUMAN
UniProt IDQ86YS7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q86YS7-1; Sequence=Displayed; Name=2; IsoId=Q86YS7-2; Sequence=VSP_028255, VSP_028256; Note=No experimental confirmation available.; Name=3; IsoId=Q86YS7-3; Sequence=VSP_028256; Note=No experimental confirmation available.; Name=4; IsoId=Q86YS7-4; Sequence=VSP_028255, VSP_055638, VSP_028256; Note=No experimental confirmation available. Ref.6 (AAI43879) sequence is in conflict in position: 895:I->F. {ECO:0000305}; Name=5; IsoId=Q86YS7-5; Sequence=VSP_028255, VSP_055639, VSP_055640; Note=No experimental confirmation available. Ref.4 (BAG58665) sequence is in conflict in position: 895:S->P. {ECO:0000305};
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 2 calcium ions per subunit. The ions are bound to the C2 domains.;
DomainThe C2 domain binds to calcium and membrane lipids.
FunctionRequired for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}.
PtmPhosphorylated on Ser-197 by active myristoylated kinase AKT2; insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane. {ECO:0000269|PubMed:18220336, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:19369195, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231, ECO:0000269|PubMed:21406692, ECO:0000269|PubMed:21907143}.
Sequence CautionSequence=BAA25454.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG58665.1; Type=Frameshift; Positions=33; Evidence={ECO:0000305};
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCytoplasmic vesicle membrane {ECO:0000269|PubMed:21907143}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21907143}. Cell membrane {ECO:0000269|PubMed:21907143}. Cell projection, ruffle {ECO:0000269|PubMed:21907143}. Note=Dynamically associated with GLUT4-containing glucose storage vesicles (GSV) and plasma membrane in response to insulin stimulation.
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