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MGP004032

UniProt Annotations

Entry Information
Gene Namemediator complex subunit 24
Protein EntryMED24_HUMAN
UniProt IDO75448
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75448-1; Sequence=Displayed; Name=2; IsoId=O75448-2; Sequence=VSP_041125;
FunctionComponent of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:16595664}.
InteractionQ9Y2X0:MED16; NbExp=2; IntAct=EBI-394523, EBI-394541;
Sequence CautionSequence=BAA09479.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the Mediator complex subunit 24 family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000305}.
SubunitComponent of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR. {ECO:0000269|PubMed:10024883, ECO:0000269|PubMed:10235266, ECO:0000269|PubMed:10235267, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:15175163, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16595664, ECO:0000269|PubMed:9637681}.
Tissue SpecificityUbiquitous. Abundant in skeletal muscle, heart and placenta. {ECO:0000269|PubMed:9653119}.
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