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MGP004037

UniProt Annotations

Entry Information
Gene NameSEC24 family member D
Protein EntrySC24D_HUMAN
UniProt IDO94855
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O94855-1; Sequence=Displayed; Name=2; IsoId=O94855-2; Sequence=VSP_035761; Note=No experimental confirmation available.;
FunctionComponent of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
Sequence CautionSequence=BAA34475.2; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the SEC23/SEC24 family. SEC24 subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}.
SubunitCOPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1. Interacts with TMED2 and TMED10. {ECO:0000269|PubMed:20427317}.
Tissue SpecificityUbiquitously expressed, with higher amounts in placenta, pancreas, heart and liver.
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