MGP Database

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MGP004044

UniProt Annotations

Entry Information
Gene Namesynaptic vesicle glycoprotein 2A
Protein EntrySV2A_HUMAN
UniProt IDQ7L0J3
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L0J3-1; Sequence=Displayed; Name=2; IsoId=Q7L0J3-2; Sequence=VSP_019265; Note=No experimental confirmation available.;
FunctionPlays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). {ECO:0000250}.
MiscellaneousIdentified as the brain binding-site for the antiepileptic drug levetiracetam/lev.
PtmN-glycosylated. {ECO:0000250}.
PtmPhosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. {ECO:0000250}.
Sequence CautionSequence=BAA34456.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12573.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the major facilitator superfamily. {ECO:0000305}.
Subcellular LocationCell junction, synapse {ECO:0000250|UniProtKB:Q9JIS5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q02563}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02563}. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic- like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q02563, ECO:0000250|UniProtKB:Q9JIS5}.
SubunitInteracts with SYT1/synaptotagmin-1 in a calcium- dependent manner. Binds the adapter protein complex AP-2 (By similarity). {ECO:0000250}.
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