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MGP Database

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MGP004046

UniProt Annotations

Entry Information

Gene Name	mannose receptor, C type 2
Protein Entry	MRC2_HUMAN
UniProt ID	Q9UBG0
Species	Human

Comments

Comment type	Description
Domain	C-type lectin domains 3 to 8 are not required for calcium- dependent binding of mannose, fucose and N-acetylglucosamine. C- type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.
Domain	Fibronectin type-II domain mediates collagen-binding.
Domain	Ricin B-type lectin domain contacts with the second C-type lectin domain. {ECO:0000250}.
Function	May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). {ECO:0000269\|PubMed:10683150, ECO:0000269\|PubMed:12972549}.
Ptm	N-glycosylated. {ECO:0000269\|PubMed:10683150, ECO:0000269\|PubMed:19139490, ECO:0000269\|PubMed:19159218}.
Sequence Caution	Sequence=BAA31684.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity	Contains 1 fibronectin type-II domain. {ECO:0000255\|PROSITE-ProRule:PRU00479}.
Similarity	Contains 1 ricin B-type lectin domain. {ECO:0000255\|PROSITE-ProRule:PRU00174}.
Similarity	Contains 8 C-type lectin domains. {ECO:0000255\|PROSITE-ProRule:PRU00040}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Subunit	Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V. {ECO:0000250, ECO:0000269\|PubMed:10636902}.
Tissue Specificity	Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269\|PubMed:10683150, ECO:0000269\|PubMed:8702911}.
Web Resource	Name=Functional Glycomics Gateway - Glycan Binding; Note=Endo180; URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_251";