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MGP004047

UniProt Annotations

Entry Information
Gene Namekelch-like family member 21
Protein EntryKLH21_HUMAN
UniProt IDQ9UJP4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UJP4-1; Sequence=Displayed; Name=2; IsoId=Q9UJP4-2; Sequence=VSP_032563, VSP_032564; Note=Ref.1 (BAA32314) sequence is in conflict in position: 534:G->D. {ECO:0000305};
FunctionSubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:19995937}.
PathwayProtein modification; protein ubiquitination.
Sequence CautionSequence=BAA32314.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 BACK (BTB/Kelch associated) domain. {ECO:0000305}.
SimilarityContains 1 BTB (POZ) domain. {ECO:0000255|PROSITE- ProRule:PRU00037}.
SimilarityContains 6 Kelch repeats. {ECO:0000305}.
Subcellular LocationCytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19995937}. Note=Localizes to the spindle midzone and targets CUL3 to this region.
SubunitComponent of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1. {ECO:0000269|PubMed:19995937}.
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