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MGP004058

UniProt Annotations

Entry Information
Gene Nameglutamine-fructose-6-phosphate transaminase 2
Protein EntryGFPT2_HUMAN
UniProt IDO94808
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityL-glutamine + D-fructose 6-phosphate = L- glutamate + D-glucosamine 6-phosphate.
FunctionControls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
PathwayNucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D- glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D- fructose 6-phosphate: step 1/1.
SimilarityContains 1 glutamine amidotransferase type-2 domain. {ECO:0000255|PROSITE-ProRule:PRU00609}.
SimilarityContains 2 SIS domains. {ECO:0000255|PROSITE- ProRule:PRU00797}.
Tissue SpecificityHighest levels of expression in heart, placenta, and spinal cord.
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