MGP Database

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MGP004075

Ontology/Pathway Information

Entrez Gene ID9978
Gene Namering-box 1, E3 ubiquitin protein ligase
Gene Symbol RBX1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0031462 IDA:UniProtKBCCul2-RING ubiquitin ligase complex
GO:0031463 IDA:UniProtKBCCul3-RING ubiquitin ligase complex
GO:0031464 IDA:UniProtKBCCul4A-RING E3 ubiquitin ligase complex
GO:0031465 IDA:UniProtKBCCul4B-RING E3 ubiquitin ligase complex
GO:0031466 IDA:UniProtKBCCul5-RING ubiquitin ligase complex
GO:0031467 IDA:UniProtKBCCul7-RING ubiquitin ligase complex
GO:0031461 IDA:MGICcullin-RING ubiquitin ligase complex
GO:0005829 ISS:UniProtKBCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0019005 IDA:UniProtKBCSCF ubiquitin ligase complex
GO:0030891 IEA:EnsemblCVCB complex
GO:0097602 IDA:MGIFcullin family protein binding
GO:0016874 IEA:UniProtKB-KWFligase activity
GO:0019788 IDA:UniProtKBFNEDD8 transferase activity
GO:0061630 IDA:MGIFubiquitin protein ligase activity
GO:0031625 IDA:UniProtKBFubiquitin protein ligase binding
GO:0034450 IDA:MGIFubiquitin-ubiquitin ligase activity
GO:0008270 IEA:InterProFzinc ion binding
GO:0071456 TAS:ReactomePcellular response to hypoxia
GO:0006281 IEA:UniProtKB-KWPDNA repair
GO:0007219 TAS:ReactomePNotch signaling pathway
GO:0043161 IDA:UniProtKBPproteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006513 IDA:UniProtKBPprotein monoubiquitination
GO:0045116 IDA:UniProtKBPprotein neddylation
GO:0016567 IDA:UniProtKBPprotein ubiquitination
GO:0061418 TAS:ReactomePregulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0031146 IDA:UniProtKBPSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0016032 TAS:ReactomePviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_264511AMER1 mutants destabilize the destruction complex
REACT_75842Antigen processing: Ubiquitination & Proteasome degradation
REACT_263859APC truncation mutants are not K63 polyubiquitinated
REACT_263992APC truncation mutants have impaired AXIN binding
REACT_264030AXIN missense mutants destabilize the destruction complex
REACT_264496AXIN mutants destabilize the destruction complex, activating WNT signaling
REACT_120956Cellular responses to stress
REACT_121311Cellular response to hypoxia
REACT_75820Class I MHC mediated antigen processing & presentation
REACT_160254Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REACT_160243Constitutive Signaling by NOTCH1 PEST Domain Mutants
REACT_75790Cytokine Signaling in Immune system
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_264438degradation of DVL
REACT_268156Degradation of GLI1 by the proteasome
REACT_267700Degradation of GLI2 by the proteasome
REACT_263937deletions in the AMER1 gene destabilize the destruction complex
REACT_264286deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
REACT_116125Disease
REACT_160099FBXW7 Mutants and NOTCH1 in Cancer
REACT_268366GLI3 is processed to GLI3R by the proteasome
REACT_268323Hedgehog 'off' state
REACT_268718Hedgehog 'on' state
REACT_6185HIV Infection
REACT_6288Host Interactions of HIV factors
REACT_6900Immune System
REACT_22442Interleukin-1 signaling
REACT_160305Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
REACT_264092misspliced GSK3beta mutants stabilize beta-catenin
REACT_264594misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_118780NOTCH1 Intracellular Domain Regulates Transcription
REACT_116022Nuclear signaling by ERBB4
REACT_120916Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
REACT_263863phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REACT_115697Prolactin receptor signaling
REACT_120815Regulation of Hypoxia-inducible Factor (HIF) by oxygen
REACT_264378RNF mutants show enhanced WNT signaling and proliferation
REACT_264581S33 mutants of beta-catenin aren't phosphorylated
REACT_264636S37 mutants of beta-catenin aren't phosphorylated
REACT_264295S45 mutants of beta-catenin aren't phosphorylated
REACT_115596Signaling by ERBB4
REACT_264508Signaling by Hedgehog
REACT_22232Signaling by Interleukins
REACT_299Signaling by NOTCH
REACT_118859Signaling by NOTCH1
REACT_160133Signaling by NOTCH1 HD Domain Mutants in Cancer
REACT_160248Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REACT_160214Signaling by NOTCH1 in Cancer
REACT_160301Signaling by NOTCH1 PEST Domain Mutants in Cancer
REACT_160082Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
REACT_11045Signaling by Wnt
REACT_264125Signaling by WNT in cancer
REACT_111102Signal Transduction
REACT_264127T41 mutants of beta-catenin aren't phosphorylated
REACT_264499TCF7L2 mutants don't bind CTBP
REACT_264596TCF dependent signaling in response to WNT
REACT_264621truncated APC mutants destabilize the destruction complex
REACT_263893truncations of AMER1 destabilize the destruction complex
REACT_9453Vif-mediated degradation of APOBEC3G
REACT_264356XAV939 inhibits tankyrase, stabilizing AXIN
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