MGP Database

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MGP004080

Ontology/Pathway Information

Entrez Gene ID10000
Gene Namev-akt murine thymoma viral oncogene homolog 3
Gene Symbol AKT3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005794 IDA:HPACGolgi apparatus
GO:0005654 IDA:HPACnucleoplasm
GO:0005886 IDA:HPACplasma membrane
GO:0005524 IDA:UniProtKBFATP binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0000002 IMP:UniProtKBPmitochondrial genome maintenance
GO:0006468 TAS:ProtIncPprotein phosphorylation
GO:0007165 IMP:UniProtKBPsignal transduction
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_549Activation of BAD and translocation to mitochondria
REACT_697Activation of BH3-only proteins
REACT_75774Adaptive Immune System
REACT_13655AKT-mediated inactivation of FOXO1A
REACT_12564AKT phosphorylates targets in the cytosol
REACT_12442AKT phosphorylates targets in the nucleus
REACT_578Apoptosis
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_964Intrinsic Pathway for Apoptosis
REACT_12447Negative regulation of the PI3K/AKT network
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_268456Programmed Cell Death
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
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