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MGP004082

UniProt Annotations

Entry Information
Gene Nameacyl-CoA thioesterase 8
Protein EntryACOT8_HUMAN
UniProt IDO14734
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCholoyl-CoA + H(2)O = cholate + CoA.
FunctionAcyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation. {ECO:0000250, ECO:0000269|PubMed:15194431}.
InductionRegulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs). {ECO:0000250}.
InteractionP04601:nef (xeno); NbExp=5; IntAct=EBI-1237371, EBI-6164028;
SimilarityBelongs to the C/M/P thioester hydrolase family. {ECO:0000305}.
Subcellular LocationPeroxisome.
SubunitInteracts with HIV-1 Nef. {ECO:0000269|PubMed:9299485}.
Tissue SpecificityDetected in a T-cell line (at protein level). Ubiquitous. {ECO:0000269|PubMed:9299485}.
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