MGP Database

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MGP004090

Ontology/Pathway Information

Entrez Gene ID10020
Gene Nameglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Gene Symbol GNE
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 TAS:ProtIncCcytoplasm
GO:0005829 IEA:EnsemblCcytosol
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004553 IEA:InterProFhydrolase activity, hydrolyzing O-glycosyl compounds
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0009384 TAS:ProtIncFN-acylmannosamine kinase activity
GO:0008761 TAS:ProtIncFUDP-N-acetylglucosamine 2-epimerase activity
GO:0046835 TAS:GOCPcarbohydrate phosphorylation
GO:0007155 TAS:ProtIncPcell adhesion
GO:0006045 IEA:UniProtKB-UniPathwayPN-acetylglucosamine biosynthetic process
GO:0006054 TAS:ProtIncPN-acetylneuraminate metabolic process
GO:0006047 IEA:InterProPUDP-N-acetylglucosamine metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_22426Asparagine N-linked glycosylation
REACT_22433Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
REACT_268132Defective ALG11 causes ALG11-CDG (CDG-1p)
REACT_267773Defective ALG12 causes ALG12-CDG (CDG-1g)
REACT_268645Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
REACT_268144Defective ALG1 causes ALG1-CDG (CDG-1k)
REACT_268833Defective ALG2 causes ALG2-CDG (CDG-1i)
REACT_268185Defective ALG3 causes ALG3-CDG (CDG-1d)
REACT_267765Defective ALG6 causes ALG6-CDG (CDG-1c)
REACT_268459Defective ALG8 causes ALG8-CDG (CDG-1h)
REACT_268015Defective ALG9 causes ALG9-CDG (CDG-1l)
REACT_268438Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
REACT_268849Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
REACT_268813Defective MAN1B1 causes MRT15
REACT_268600Defective MGAT2 causes MGAT2-CDG (CDG-2a)
REACT_267905Defective MOGS causes MOGS-CDG (CDG-2b)
REACT_268619Defective MPDU1 causes MPDU1-CDG (CDG-1f)
REACT_268458Defective RFT1 causes RFT1-CDG (CDG-1n)
REACT_116125Disease
REACT_267875Diseases associated with N-glycosylation of proteins
REACT_268324Diseases of glycosylation
REACT_17015Metabolism of proteins
REACT_22161Post-translational protein modification
REACT_264366Sialic acid metabolism
REACT_22387Synthesis of substrates in N-glycan biosythesis
SMP Pathway Links
SMP IDDescription
SMP00045Amino Sugar Metabolism
SMP00534G(M2)-Gangliosidosis: Variant B, Tay-sachs disease
SMP00240Salla Disease/Infantile Sialic Acid Storage Disease
SMP00216Sialuria or French Type Sialuria
SMP00217Sjogren Larsson Syndrome
SMP00390Tay-Sachs Disease
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