MGP Database

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MGP004091

Ontology/Pathway Information

Entrez Gene ID10021
Gene Namehyperpolarization activated cyclic nucleotide gated potassium channel 4
Gene Symbol HCN4
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005887 IBA:GO_CentralCintegral component of plasma membrane
GO:0031226 IDA:UniProtKBCintrinsic component of plasma membrane
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0043195 IEA:EnsemblCterminal bouton
GO:0030552 IEA:UniProtKB-KWFcAMP binding
GO:0005261 TAS:ProtIncFcation channel activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0005222 IDA:UniProtKBFintracellular cAMP activated cation channel activity
GO:0005249 IDA:UniProtKBFvoltage-gated potassium channel activity
GO:0005248 IMP:UniProtKBFvoltage-gated sodium channel activity
GO:0008015 NAS:ProtIncPblood circulation
GO:0006812 TAS:ProtIncPcation transport
GO:0071320 IDA:UniProtKBPcellular response to cAMP
GO:0071321 IDA:UniProtKBPcellular response to cGMP
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0006936 TAS:ProtIncPmuscle contraction
GO:0071805 IDA:UniProtKBPpotassium ion transmembrane transport
GO:0002027 IMP:UniProtKBPregulation of heart rate
GO:0042391 IMP:UniProtKBPregulation of membrane potential
GO:0035725 IMP:UniProtKBPsodium ion transmembrane transport
GO:0007268 TAS:ReactomePsynaptic transmission
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75862HCN channels
REACT_13685Neuronal System
REACT_75908Potassium Channels
SMP Pathway Links
SMP IDDescription
SMP00296Acebutolol Action Pathway
SMP00297Alprenolol Action Pathway
SMP00665Amiodarone Action Pathway
SMP00376Amlodipine Action Pathway
SMP00664Arbutamine Action Pathway
SMP00298Atenolol Action Pathway
SMP00299Betaxolol Action Pathway
SMP00668Bevantolol Action Pathway
SMP00300Bisoprolol Action Pathway
SMP00657Bopindolol Action Pathway
SMP00670Bupranolol Action Pathway
SMP00658Carteolol Action Pathway
SMP00367Carvedilol Action Pathway
SMP00359Diltiazem Action Pathway
SMP00325Disopyramide Action Pathway
SMP00662Dobutamine Action Pathway
SMP00661Epinephrine Action Pathway
SMP00301Esmolol Action Pathway
SMP00377Felodipine Action Pathway
SMP00331Flecainide Action Pathway
SMP00326Fosphenytoin (Antiarrhythmic) Action Pathway
SMP00332Ibutilide Action Pathway
SMP00663Isoprenaline Action Pathway
SMP00378Isradipine Action Pathway
SMP00368Labetalol Action Pathway
SMP00666Levobunolol Action Pathway
SMP00328Lidocaine (Antiarrhythmic) Action Pathway
SMP00667Metipranolol Action Pathway
SMP00302Metoprolol Action Pathway
SMP00329Mexiletine Action Pathway
SMP00588Muscle/Heart Contraction
SMP00303Nadolol Action Pathway
SMP00366Nebivolol Action Pathway
SMP00379Nifedipine Action Pathway
SMP00380Nimodipine Action Pathway
SMP00381Nisoldipine Action Pathway
SMP00382Nitrendipine Action Pathway
SMP00304Oxprenolol Action Pathway
SMP00305Penbutolol Action Pathway
SMP00327Phenytoin (Antiarrhythmic) Action Pathway
SMP00306Pindolol Action Pathway
SMP00669Practolol Action Pathway
SMP00324Procainamide (Antiarrhythmic) Action Pathway
SMP00307Propranolol Action Pathway
SMP00323Quinidine Action Pathway
SMP00660Sotalol Action Pathway
SMP00659Timolol Action Pathway
SMP00330Tocainide Action Pathway
SMP00375Verapamil Action Pathway
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