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MGP004103

Record overview

MGPD IDMGP004103
Gene ID10056
SpeciesHomo sapiens (Human)
Gene Namephenylalanyl-tRNA synthetase, beta subunit
Gene Symbol FARSB
SynonymsFRSB; PheHB; PheRS; FARSLB; HSPC173;
Alternate namesphenylalanine--tRNA ligase beta subunit; phenylalanine tRNA ligase 1, beta, cytoplasmic; phenylalanine--tRNA ligase beta chain; phenylalanine-tRNA ligase beta chain; phenylalanine-tRNA synthetase-like, beta subunit; phenylalanyl-tRNA synthetase beta chain; phenylalanyl-tRNA synthetase beta-subunit; phenylalanyl-tRNA synthetase-like, beta subunit;
Chromosome2
Map Location2q36.1
EC Number6.1.1.20
SummaryThis gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
OrthologsView orthologs and multiple alignments for FARSB

Proteins

phenylalanine--tRNA ligase beta subunit
Refseq ID:NP_005678
Protein GI:124028525
UniProt ID:Q9NSD9
mRNA ID:NM_005687
Length:589
RefSeq Status:
MPTVSVKRDLLFQALGRTYTDEEFDELCFEFGLELDEITSEKEIISKEQGNVKAAGASDVVLYKIDVPANRYDLLCLEGLVRGLQVFKERIKAPVYKRVM
PDGKIQKLIITEETAKIRPFAVAAVLRNIKFTKDRYDSFIELQEKLHQNICRKRALVAIGTHDLDTLSGPFTYTAKRPSDIKFKPLNKTKEYTACELMNI
YKTDNHLKHYLHIIENKPLYPVIYDSNGVVLSMPPIINGDHSRITVNTRNIFIECTGTDFTKAKIVLDIIVTMFSEYCENQFTVEAAEVVFPNGKSHTFP
ELAYRKEMVRADLINKKVGIRETPENLAKLLTRMYLKSEVIGDGNQIEIEIPPTRADIIHACDIVEDAAIAYGYNNIQMTLPKTYTIANQFPLNKLTELL
RHDMAAAGFTEALTFALCSQEDIADKLGVDISATKAVHISNPKTAEFQVARTTLLPGLLKTIAANRKMPLPLKLFEISDIVIKDSNTDVGAKNYRHLCAV
YYNKNPGFEIIHGLLDRIMQLLDVPPGEDKGGYVIKASEGPAFFPGRCAEIFARGQSVGKLGVLHPDVITKFELTMPCSSLEINVGPFL
 
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