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MGP004104

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family C (CFTR/MRP), member 5
Protein EntryMRP5_HUMAN
UniProt IDO15440
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=O15440-1; Sequence=Displayed; Name=2; Synonyms=SV1; IsoId=O15440-2; Sequence=VSP_043397, VSP_043402; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=SV2; IsoId=O15440-3; Sequence=VSP_043398, VSP_043401, VSP_043402; Note=Predominant isoform in retinal pigment epithelium, bladder, and stomach.; Name=4; Synonyms=SV3; IsoId=O15440-4; Sequence=VSP_043399, VSP_043400, VSP_043402; Name=5; IsoId=O15440-5; Sequence=VSP_055354;
FunctionActs as a multispecific organic anion pump which can transport nucleotide analogs. {ECO:0000269|PubMed:10840050}.
SimilarityBelongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
SimilarityContains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00441}.
SimilarityContains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityAll isoforms are equally expressed in retina. {ECO:0000269|PubMed:17521428}.
Web ResourceName=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15440";
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