MGP Database

MGP004123

Record overview

MGPD IDMGP004123
Gene ID10102
SpeciesHomo sapiens (Human)
Gene NameTs translation elongation factor, mitochondrial
Gene Symbol TSFM
SynonymsEFTS; EFTSMT;
Alternate nameselongation factor Ts, mitochondrial; EF-Ts; EF-TsMt; TSFM; mitochondrial elongation factor Ts;
Chromosome12
Map Location12q14.1
SummaryThis gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
OrthologsView orthologs and multiple alignments for TSFM

Proteins

elongation factor Ts, mitochondrial isoform 1 precursor
Refseq ID:NP_001166167
Protein GI:291084500
UniProt ID:P43897
mRNA ID:NM_001172696
Length:346
RefSeq Status:
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGR
KTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKVQWLTPVNLALWEAEAGGSLEGFLNSSELSGLPAGPDRE
GSLKDQLALAIGKLGENMILKRAAWVKVPSGFYVGSYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEA
ETKMLSQPYLLDPSITLGQYVQPQGVSVVDFVRFECGEGEEAAETE
 
transit_peptide: 1..14
inference: protein motif:TargetP:1.1
note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction.
calculated_mol_wt: 1661
peptide sequence: 
MSLLRSLRVFLVAR

mat_peptide: 15..325
product: elongation factor Ts, mitochondrial isoform 2
calculated_mol_wt: 33748
peptide sequence: 
TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGKLGENMILKRAAWVKVPSGFYVG
SYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYVQPQGVSVVDFVRFE
CGEGEEAAETE transit_peptide: 1..14 inference: protein motif:TargetP:1.1 note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction. calculated_mol_wt: 1661 peptide sequence: MSLLRSLRVFLVAR mat_peptide: 15..215 product: elongation factor Ts, mitochondrial isoform 4 calculated_mol_wt: 21914 peptide sequence: TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGLPFQIGAVSELQLPESNFLQNTS
S transit_peptide: 1..14 inference: protein motif:TargetP:1.1 note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction. calculated_mol_wt: 1661 peptide sequence: MSLLRSLRVFLVAR mat_peptide: 15..167 product: elongation factor Ts, mitochondrial isoform 3 calculated_mol_wt: 17105 peptide sequence: TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKENWEKT transit_peptide: 1..14 inference: protein motif:TargetP:1.1 note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction. calculated_mol_wt: 1661 peptide sequence: MSLLRSLRVFLVAR mat_peptide: 15..346 product: elongation factor Ts, mitochondrial isoform 1 calculated_mol_wt: 36013 peptide sequence: TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKVQWLTPVNLALWEAEAGGSLEGFLNSSELSGLPAGPDREGSLKDQLALAIGKL
GENMILKRAAWVKVPSGFYVGSYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPS
ITLGQYVQPQGVSVVDFVRFECGEGEEAAETE
 
elongation factor Ts, mitochondrial isoform 2 precursor
Refseq ID:NP_005717
Protein GI:171846268
UniProt ID:P43897
mRNA ID:NM_005726
Length:325
RefSeq Status:
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGR
KTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGKLGENMILK
RAAWVKVPSGFYVGSYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYV
QPQGVSVVDFVRFECGEGEEAAETE
 
transit_peptide: 1..14
inference: protein motif:TargetP:1.1
note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction.
calculated_mol_wt: 1661
peptide sequence: 
MSLLRSLRVFLVAR

mat_peptide: 15..325
product: elongation factor Ts, mitochondrial isoform 2
calculated_mol_wt: 33748
peptide sequence: 
TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGKLGENMILKRAAWVKVPSGFYVG
SYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYVQPQGVSVVDFVRFE
CGEGEEAAETE
 
elongation factor Ts, mitochondrial isoform 3 precursor
Refseq ID:NP_001166166
Protein GI:291084498
UniProt ID:P43897
mRNA ID:NM_001172695
Length:167
RefSeq Status:
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGR
KTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKENWEKT
 
transit_peptide: 1..14
inference: protein motif:TargetP:1.1
note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction.
calculated_mol_wt: 1661
peptide sequence: 
MSLLRSLRVFLVAR

mat_peptide: 15..325
product: elongation factor Ts, mitochondrial isoform 2
calculated_mol_wt: 33748
peptide sequence: 
TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGKLGENMILKRAAWVKVPSGFYVG
SYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYVQPQGVSVVDFVRFE
CGEGEEAAETE transit_peptide: 1..14 inference: protein motif:TargetP:1.1 note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction. calculated_mol_wt: 1661 peptide sequence: MSLLRSLRVFLVAR mat_peptide: 15..215 product: elongation factor Ts, mitochondrial isoform 4 calculated_mol_wt: 21914 peptide sequence: TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGLPFQIGAVSELQLPESNFLQNTS
S transit_peptide: 1..14 inference: protein motif:TargetP:1.1 note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction. calculated_mol_wt: 1661 peptide sequence: MSLLRSLRVFLVAR mat_peptide: 15..167 product: elongation factor Ts, mitochondrial isoform 3 calculated_mol_wt: 17105 peptide sequence: TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKENWEKT
 
elongation factor Ts, mitochondrial isoform 4 precursor
Refseq ID:NP_001166168
Protein GI:291084502
UniProt ID:P43897
mRNA ID:NM_001172697
Length:215
RefSeq Status:
MSLLRSLRVFLVARTGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGR
KTKEGLIGLLQEGNTTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGLPFQIGAVS
ELQLPESNFLQNTSS
 
transit_peptide: 1..14
inference: protein motif:TargetP:1.1
note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction.
calculated_mol_wt: 1661
peptide sequence: 
MSLLRSLRVFLVAR

mat_peptide: 15..325
product: elongation factor Ts, mitochondrial isoform 2
calculated_mol_wt: 33748
peptide sequence: 
TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGKLGENMILKRAAWVKVPSGFYVG
SYVHGAMQSPSLHKLVLGKYGALVICETSEQKTNLEDVGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYVQPQGVSVVDFVRFE
CGEGEEAAETE transit_peptide: 1..14 inference: protein motif:TargetP:1.1 note: The cleavage site of the target peptide has not been experimentally determined. The annotated site is inferred from TargetP prediction. calculated_mol_wt: 1661 peptide sequence: MSLLRSLRVFLVAR mat_peptide: 15..215 product: elongation factor Ts, mitochondrial isoform 4 calculated_mol_wt: 21914 peptide sequence: TGSYPAGSLLRQSPQPRHTFYAGPRLSASASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEIWLHKEAQKEGWSKAAKLQGRKTKEGLIGLLQEGN
TTVLVEVNCETDFVSRNLKFQLLVQQVALGTMMHCQTLKDQPSAYSKGFLNSSELSGLPAGPDREGSLKDQLALAIGLPFQIGAVSELQLPESNFLQNTS
S
 
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